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KMID : 0861019980130020037
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Korea Journal of Herbology
1998 Volume.13 No. 2 p.37 ~ p.43
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Effects of Safflower Seeds on Bone Mineral Density in Ovariectomy - Induced Postmenopausal Osteoporotic Rats
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金美麗/Kim, Mi Ryeo
梁在夏/徐富一/Yang, Chae Ha/Seo, Bu Il
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Abstract
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Effects of safflower seeds water extract on bone mineral density(BMD) was investigated in ovariectomy- induced postmenopausal osteoporotic rats. BMD of spine, relvis, right femur and tibia were measured in ovariectomized(OVX) rats treated with safflower seeds water extract(1250㎎/㎏ BW) or placebo for 4 weeks. Ovariectomy caused a significant decrease in spinal, right femoral and tibial BMD after 2 and 4 weeks, respectively. Compared with OVX rats, safflower seeds water extract(1250㎎/㎏ BW) caused significant increase in spinal, pelvic, right femoral and tibial BMD at 2 and 4 weeks after treatment, respectively. These findings suggest a possible protective effect of safflower seeds water extract(1250㎎/㎏ BW) against bone loss in OVX rats, associated with increase in serum estradiol level.
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KEYWORD
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